The Culture of Manchester is notable artistically, architecturally, theatrically and musically. Despite being the 5th largest city in the United Kingdom by population and the second largest conurbation, Manchester has been ranked as the second city of the United Kingdom in numerous polls since the 2000s (decade), with an influential culture scene helping to elevate Manchester's importance in the national psyche. This has helped the city's population grow by 20% in the last decade, and made the universities the most popular choices for undergraduate admission.

Its main pop music venue is Manchester Arena, voted "International Venue of the Year" in 2007 With over 21,000 seats, it is the largest arena of its type in Europe. In terms of concertgoers, it is the busiest indoor arena in the world, ahead of Madison Square Garden in New York and The O2 Arena in London, which are second and third busiest. Other venues include Manchester Apollo, Albert Hall, Victoria Warehouse and the Manchester Academy. Smaller venues include the Band on the Wall, the Night and Day Café, the Ruby Lounge, and The Deaf Institute. Manchester also has the most indie and rock music events outside London.

Manchester has two symphony orchestras, the Hallé and the BBC Philharmonic, and a chamber orchestra, the Manchester Camerata. In the 1950s, the city was home to a so-called "Manchester School" of classical composers, which was composed of Harrison Birtwistle, Peter Maxwell Davies, David Ellis and Alexander Goehr. Manchester is a centre for musical education: the Royal Northern College of Music and Chetham's School of Music.

 Forerunners of the RNCM were the Northern School of Music (founded 1920) and the Royal Manchester College of Music (founded 1893), which merged in 1973. One of the earliest instructors and classical music pianists/conductors at the RMCM, shortly after its founding, was the Russian-born Arthur Friedheim, (1859–1932), who later had the music library at the famed Peabody Institute conservatory of music in Baltimore, Maryland, named after him. The main classical music venue was the Free Trade Hall on Peter Street until the opening in 1996 of the 2,500 seat Bridgewater Hall.

Brass band music, a tradition in the north of England, is important to Manchester's musical heritage; some of the UK's leading bands, such as the CWS Manchester Band and the Fairey Band, are from Manchester and surrounding areas, and the Whit Friday brass-band contest takes place annually in the neighbouring areas of Saddleworth and Tameside.